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Subacute cutaneous lupus erythematosus (SCLE) is a clinically distinct subset of lupus erythematosus that is most often present in white women aged 15 to 40. Lupus erythematosus may manifest itself as systemic disease or in a purely cutaneous form also known as incomplete lupus erythematosus with non-scarring, non-indurated, photosensitive, non ...
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Get PriceBackground Subacute cutaneous lupus erythematosus (SCLE) lacks consensus diagnostic criteria and the pathogenesis is poorly understood. There are increasing reports of SCLE induced by monoclonal antibodies (mAbs), but there are limited data on the aetiology, clinical characteristics and natural course of this disease. Methods We devised a set of diagnostic criteria for SCLE in collaboration ...
Get PriceSubacute cutaneous lupus erythematosus (SCLE) is a clinically distinct form of CLE that presents as a highly photosensitive annular-polycyclic or papulosquamous eruption distributed symmetrically on sun-exposed areas (Figure 1). The upper back, chest, shoulders and extensor arms are frequent sites. Lesions below the waist are uncommon.
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Get PriceStrongly associated with systemic findings. Inflammatory infiltrate seen in the superficial dermis on biopsy. Subacute cutaneous lupus erythematosus (SCLE) Photosensitive cutaneous eruption lasting longer than ACLE but without scarring. 10%-15% of patients go on to have systemic findings. Inflammatory infiltrate seen in the upper dermis on biopsy.
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Get PriceSubacute Cutaneous Lupus Erythematosus (SCLE) is a particular form of lupus that affects the skin, causing red, itchy rashes. This particular type of lupus can have 2 common manifestations: "One type begins with red, pimple-like bumps on the skin and can develop into red, scaly lesions that resemble psoriasis," says Dr. Kellie Reed ...
Get PricePerniosis : Painful erythematous or edematous nodules on acral skin following exposure to cold. Clinical context variable: chronic cutaneous lupus erythematosus (CCLE) without systemic disease, chilblain lupus erythematosus in the context of systemic lupus erythematosus, idiopathic perniosis and COVID-19. Vacuolar interface change is common.
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Get PriceThis activity will discuss subacute cutaneous lupus erythematosus (SCLE). SCLE is a subtype of CLE presenting as symmetric, non-scarring photosensitive erythematous rash usually over syn-exposed areas like face, neck, arms, upper back, and shoulders. Etiology. There is no well-defined etiology for systemic lupus erythematosus.
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Get PriceSubacute cutaneous lupus erythematosus (SCLE) is a distinct subset of cutaneous lupus erythematosus and was first described by Sontheimer et al. in 1979. Clinically, SCLE presents with erythematous nonscarring annular or papulosquamous eruptions on photo-exposed areas such as upper back, chest, dorsal arms, and lateral neck.
Get PriceJYP Journal of Young Pharmacists 0975-1505 India JYoungPharm-11-1-108 / Case Report Case Report on a Rare Adverse Drug Reaction of Cefotaxime Induced Subacute Cutaneous Lupus Erythematosus Clement Kabakama`C 1 Nalini Nandhi 2 * 1Department of Pharmacy Practice, JSS College of Pharmacy, Ootacamund, The Nilgiris, Tamil Nadu INDIA. 2Pediatrician and
Get PriceDrug-induced subacute cutaneous lupus erythematosus is an uncommon disorder associated with the use of pharmacological agents including systemic chemotherapy. We report a case of docetaxel-induced subacute cutaneous lupus erythematosus in a 60-year-old Caucasian with Sjögren's syndrome diagnosed 2 months after receiving docetaxel as part of the adjuvant FEC-D (5-fluorouracil ...
Get PriceSCLE can occur anywhere on your body except your face, and like other types of cutaneous lupus, is often triggered by sunlight. Certain prescription drugs can also cause SCLE, especially some heart medications, proton pump inhibitors, anti-fungals, chemotherapy medications and tumor necrosis factor blockers. In one of the largest case studies ...
Get PriceThere were 64 SCLE patients: 36 with PPI-induced SCLE and 28 patients with primary SCLE. Results: Twenty-six patients (72%) had pre-existing SLE in the PPI-induced SCLE group. Lower limb skin lesions were significantly more prevalent in the PPI group (p < ). The prevalence of anti-Ro and anti-Ro-52 antibodies was numerically higher in the ...
Get PriceThe primary lesion of subacute cutaneous lupus erythematosus (SCLE) is an erythematous papule or a small plaque, often with slight scaling. Primary lesions expand and may merge and eventually form either plaques with scaling, in the papulosquamous variant, or annular and/or polycyclic lesions, in the annular variant.
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Get PriceDrug-induced subacute cutaneous lupus erythematosus (DI-SCLE) is subacute cutaneous lupus erythematosus (SCLE) in which the disease onset is associated with the ingestion of an offending medication. It is estimated that approximately one-third of all SCLE cases are Idiopathic SCLE and DI-SCLE are serologically, histopathologically, and clinically identical, with both ...
Get PriceSubacute cutaneous lupus erythematosus (SCLE) is a clinically distinct disease that is associated with systemic lupus erythematosus in 50% of patients, and can be associated with Sjögren's syndrome and patients with a deficiency in the second and fourth components of complement. SCLE presents as a small, erythematous, scaly papular eruption in a photosensitive distribution that subsequently ...
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Get PriceSubset of lupus erythematosus intermediate between discoid lupus erythematosus and systemic lupus erythematosus. It is characterized by papulosquamous discoid plaques or annular polycyclic lesions occurring mainly around the neck, on the back and front of the trunk and on the outer aspects of the arms. They usually heal without scarring. Photosensitivity, diffuse non-scarring alopecia and ...
Get PriceSubacute cutaneous lupus erythematosus (SCLE) is a subtype of Cutaneous Lupus Erythematosus that usually manifests as non-scarring annular, polycyclic erythematous scaly plaques or confluent papulosquamous (psoriasiform) lesions on sun-exposed skin with limited systemic involvement [3,4]. Most common areas
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Get PriceWe report here 5 additional cases of subacute cutaneous lupus erythematosus (SCLE) induced or exacerbated by PPIs, with a detailed summary of 2 cases. CASE REPORTS. Case 1. A 63-year-old woman with Addison's disease had been substituted with per-oral hydrocortisone, 25 mg daily, for 41 years. Fourteen years earlier she had an attack of SCLE ...
Get PriceHypopigmentation in subacute cutaneous lupus erythematosus (SCLE). Permanent vitiligo-like depigmentation in the face of a patient with SCLE (Callen and Klein 1988, David et al. 1984, Molad et al. 1987, Shou-yi et al. 1987, Sontheimer 1985a, Sontheimer et al. 1979). These lesions can predate the onset of SCLE lesions; however, DLE lesions are ...
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Get PriceSubacute cutaneous lupus due to protein pump inhibitors (PPI-induced SCLE) is more likely to affect the legs than SCLE that occurs on its own (primary SCLE) It took from 3 weeks to 12 years after starting the PPI before SCLE occurred (median time was 8 months) It took 1 week to 5 months for the SCLE to resolve after stopping the PPI. Increased ...
Get PriceSubacute cutaneous lupus erythematosus (SCLE) is a distinct entity with specific clinical and serologic features that was first described by Gilliam in 1977 (Gilliam, 1977), with expanded discussion in 1979 (Sontheimer et al., 1979) and 1982 (Gilliam and Sontheimer, 1982). Most patients with SCLE are sensitive to sunlight and have prominent cutaneous and musculoskeletal complaints but ...
Get PriceSubacute cutaneous lupus erythematosus (SCLE) is a variant of systemic lupus erythematosus. The body's immune system mistakenly attacks healthy skin tissue. Factors such as skin exposure, and certain drugs may exacerbate the condition. A common symptom of SCLE are skin lesions that are scaly.
Get PriceThe initial appearance of subacute cutaneous lupus erythematosus (SCLE) skin lesions in conjunction with Ro/SS-A autoantibodies occurring as an adverse reaction to hydrochlorothiazide [ drug ...
Get PriceJAMA Dermatol. 2022; 149 (9):1071-5 (ISSN: 2168-6084) IMPORTANCE: Several chemotherapeutic agents have been reported to induce subacute cutaneous lupus erythematosus (SCLE). To our knowledge, this is the first report to date of SCLE induced by monotherapeutic gemcitabine hydrochloride and includes a comprehensive review of all published cases ...
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Get PriceLupus erythematosus (LE) is an inflammatory connective tissue disorder characterized by pathogenic autoantibodies, immune complex formation, deposition, and attributed to the loss of immune tolerance. Dermatological manifestations of lupus constitute one of the diagnostic criteria for systemic lupus erythematosus (SLE). Cutaneous findings in lupus encompass a broad spectrum of findings and may ...
Get PriceSubacute Cutaneous Lupus Erythematosus. Subacute cutaneous lupus erythematosus is associated with specific clinical, serologic, and genetic characteristics (Box ), and was recognized as a distinct entity by Gilliam in 1977. 6 SCLE frequently is associated with systemic symptoms such as arthritis and a pronounced photosensitivity but normally has a favorable prognosis.
Get PriceThe SCLE subtype of cutaneous lupus erythematosus is an autoimmune disease that primarily affects the skin (2). Up to 50% of the SCLE patients manifest criteria for systemic LE (SLE) but with a mild systemic disease evolution (3). The SCLE patients manifesting SLE features show a lower incidence of renal disease, and the central nervous system ...
Get PriceProton pump inhibitors (PPIs) are associated with very infrequent cases of subacute cutaneous lupus erythematosus (SCLE), a non-scarring dermatosis that can develop in sun-exposed areas.
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